{"id":182163,"date":"2017-08-22T00:00:00","date_gmt":"2017-08-21T22:00:00","guid":{"rendered":"https:\/\/www.bcfi.be\/commentaire-controverses-concernant-lelargissement-des-indications-de-lempagliflozine-2\/"},"modified":"2017-08-22T00:00:00","modified_gmt":"2017-08-21T22:00:00","slug":"commentaire-controverses-concernant-lelargissement-des-indications-de-lempagliflozine-2","status":"publish","type":"post","link":"https:\/\/h.cbip.be\/fr\/commentaire-controverses-concernant-lelargissement-des-indications-de-lempagliflozine-2\/","title":{"rendered":"Commentaire: controverses concernant l\u2019\u00e9largissement des indications de l\u2019empagliflozine"},"content":{"rendered":"<p>Dans les <a href=&quot;https:\/\/www.cbip.be\/fr\/articles\/2716?folia=2710&quot;>Folia d\u2019avril 2017<\/a>&#x002C; il a \u00e9t\u00e9 signal\u00e9 que&#x002C; sur base des r\u00e9sultats de l\u2019\u00e9tude EMPA-REG&#x002C; les indications de l\u2019empagliflozine ont \u00e9t\u00e9 \u00e9largies \u00e0 la protection cardio-vasculaire&#x002C; ce qui a suscit\u00e9 des discussions en raison entre autres des limites de l\u2019\u00e9tude EMPA-REG [<a href=&quot;https:\/\/www.cbip.be\/fr\/articles\/2293?folia=2272&quot;>voir Folia de novembre 2015<\/a> et <a href=&quot;https:\/\/www.cbip.be\/fr\/articles\/2686?folia=2683&quot;>Folia de f\u00e9vrier 2017<\/a>].<\/p>\n<p>Outre le fait que l\u2019\u00e9tude EMPA-REG n\u2019\u00e9tait pas con\u00e7ue pour \u00e9valuer l\u2019efficacit\u00e9 cardio-vasculaire de l\u2019empagliflozine&#x002C; un commentaire paru dans <a href=&quot;https:\/\/www.nps.org.au\/medical-info\/clinical-topics\/news\/new-tga-indication-for-empagliflozin&quot;>NPS Medicinewise<\/a> (une organisation d\u2019information ind\u00e9pendante similaire au CBIP en Australie) attire \u00e9galement l\u2019attention sur le fait que 124 d\u00e9c\u00e8s jug\u00e9s \u00ab\u00a0non \u00e9valuables\u00a0\u00bb ont \u00e9t\u00e9 assimil\u00e9s aux d\u00e9c\u00e8s cardio-vasculaires&#x002C; ce qui a eu une influence sur le nombre total de d\u00e9c\u00e8s cardiovasculaires et\u00a0 sur le crit\u00e8re d\u2019\u00e9valuation primaire. Une analyse de sensibilit\u00e9 a en effet montr\u00e9 que si l\u2019on ne tient pas compte de ces d\u00e9c\u00e8s jug\u00e9s non \u00e9valuables&#x002C; l\u2019empagliflozine n\u2019est pas sup\u00e9rieure au placebo pour r\u00e9duire le crit\u00e8re d\u2019\u00e9valuation primaire combin\u00e9 (mortalit\u00e9 cardio-vasculaire&#x002C; infarctus du myocarde non fatal et AVC non fatal). Il y a cependant toujours une diminution de la mortalit\u00e9 cardio-vasculaire et de la mortalit\u00e9 totale \u00e9valu\u00e9es s\u00e9par\u00e9ment.<\/p>\n<p>Ces limitations renforcent le point de vue du CBIP que les r\u00e9sultats de l\u2019\u00e9tude EMPA-REG ne permettent pas de tirer des conclusions d\u00e9finitives quant \u00e0 la r\u00e9duction des complications cardio-vasculaires \u00e0 long terme du diab\u00e8te.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dans les Folia d\u2019avril 2017&#x002C; il a \u00e9t\u00e9 signal\u00e9 que&#x002C;  [&#8230;]<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,175],"tags":[20213],"class_list":["post-182163","post","type-post","status-publish","format-standard","hentry","category-actualites","category-2017-fr","tag-import_tags"],"_links":{"self":[{"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/posts\/182163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/comments?post=182163"}],"version-history":[{"count":0,"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/posts\/182163\/revisions"}],"wp:attachment":[{"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/media?parent=182163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/categories?post=182163"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/tags?post=182163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}