{"id":175321,"date":"2023-04-07T00:00:00","date_gmt":"2023-04-06T22:00:00","guid":{"rendered":"https:\/\/www.bcfi.be\/le-rimegepant-une-nouvelle-option-therapeutique-pour-la-migraine\/"},"modified":"2026-04-09T17:10:33","modified_gmt":"2026-04-09T15:10:33","slug":"le-rimegepant-une-nouvelle-option-therapeutique-pour-la-migraine","status":"publish","type":"post","link":"https:\/\/h.cbip.be\/fr\/le-rimegepant-une-nouvelle-option-therapeutique-pour-la-migraine\/","title":{"rendered":"Le rim\u00e9g\u00e9pant : une nouvelle option th\u00e9rapeutique pour la migraine"},"content":{"rendered":"<div class='summary'>Le rim&eacute;g&eacute;pant appartient &agrave; la classe des antagonistes des r&eacute;cepteurs du peptide li&eacute; au g&egrave;ne de la calcitonine<i> <\/i>(CGRP)&#x002C; une nouvelle classe de m&eacute;dicaments pour la migraine appel&eacute;s &laquo;&nbsp;g&eacute;pants&nbsp;&raquo;.<br \/> &nbsp;<br \/> Que ce soit en aigu ou en prophylaxie&#x002C; l&rsquo;effet du rim&eacute;g&eacute;pant est plut&ocirc;t modeste. Avec le rim&eacute;g&eacute;pant&#x002C; la douleur avait disparu 2 heures apr&egrave;s la prise chez 5 &agrave; 16% de patients suppl&eacute;mentaires&#x002C; par rapport au placebo. L&#39;administration prophylactique de rim&eacute;g&eacute;pant (tous les deux jours) permet d&rsquo;&eacute;viter moins d&#39;un jour de migraine dans le troisi&egrave;me mois suivant le d&eacute;but du traitement&#x002C; par rapport au placebo.<br \/> &nbsp;<br \/> Des &eacute;tudes comparatives directes sont n&eacute;cessaires entre le rim&eacute;g&eacute;pant et les autres traitements m&eacute;dicamenteux utilis&eacute;s dans la migraine aigu&euml; ou en prophylaxie.<br \/> &nbsp;<br \/> Le rim&eacute;g&eacute;pant pourrait &ecirc;tre une alternative int&eacute;ressante pour les patients qui ne r&eacute;pondent pas suffisamment aux triptans ou qui pr&eacute;sentent des contre-indications aux triptans&#x002C; mais ce groupe n&rsquo;a pas encore &eacute;t&eacute; &eacute;tudi&eacute;.<br \/> &nbsp;<br \/> Il n&#39;existe pas non plus d&#39;&eacute;tudes randomis&eacute;es sur l&#39;utilit&eacute; du rim&eacute;g&eacute;pant en traitement de crise chez les patients prenant d&eacute;j&agrave; du rim&eacute;g&eacute;pant &agrave; titre prophylactique ou recevant un autre traitement prophylactique.<\/p>\n<p> Des recherches suppl&eacute;mentaires sont n&eacute;cessaires pour &eacute;valuer l&rsquo;efficacit&eacute; et la s&eacute;curit&eacute; &agrave; long terme du rim&eacute;g&eacute;pant.<\/p><\/div>\n<h2>Les antagonistes du r&eacute;cepteur du CGRP : une nouvelle classe d&rsquo;antimigraineux<\/h2>\n<ul>\n<li>\n<p>Le rim&eacute;g&eacute;pant est le premier antimigraineux autoris&eacute; en Europe d&rsquo;une nouvelle classe de m&eacute;dicaments antimigraineux : les petites mol&eacute;cules antagonistes (<a>non-peptidiques<\/a>) des r&eacute;cepteurs du peptide reli&eacute; au g&egrave;ne de la calcitonine (CGRP)&#x002C; aussi appel&eacute;es les &laquo;&nbsp;<strong>g&eacute;pants&nbsp;&raquo;<\/strong>. Le CGRP est un neuropeptide impliqu&eacute; dans la physiopathologie de la migraine<span class='folia-referentie-nummer'><sup>1<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]-->.<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span><span style=\u2019mso-bookmark:_Hlk130282200\u2019> ADDIN EN.CITE <EndNote><Cite><Author>Heersche<\/Author><Year>2018<\/Year><RecNum>17410<\/RecNum><DisplayText>\n\n<style face='superscript'>1<\/style>\n\n<\/DisplayText><record><rec-number>17410<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>17410<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>Heersche&#x002C;A. <\/author><author>Bijlstra-Cramer&#x002C;M. A. <\/author><\/authors><\/contributors><titles><title>Erenumab; de eerste CGRP-antagonist bij migraine<\/title><secondary-title>Pharma Selecta<\/secondary-title><\/titles><pages>65-68<\/pages><volume>34<\/volume><dates><year>2018<\/year><\/dates><urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=17410.pdf<\/url><\/pdf-urls><\/urls><access-date>2018-10-01<\/access-date><modified-date>H\u00b0 Zen; TF Mig<\/modified-date><\/record><\/Cite><\/EndNote><span style=\u2019mso-element:field-separator\u2019><\/span><\/span><\/span><![endif]--><\/p>\n<\/li>\n<li>\n<p>Le rim&eacute;g&eacute;pant est administr&eacute; sous forme de lyophilisat oral (&agrave; placer sur ou sous la langue) &agrave; raison de 75 mg par lyophilisat. La posologie est de 75 mg en cas de crise aigu&euml; (maximum 1x par jour) et de 75 mg tous les deux jours en prophylaxie (maximum 75 mg par jour). Selon le RCP&#x002C; le rim&eacute;g&eacute;pant est indiqu&eacute; &agrave; la fois pour le traitement des <strong>crises de migraine<\/strong> avec ou sans aura chez l&rsquo;adulte et pour la <strong>prophylaxie de la migraine<\/strong> <strong>&eacute;pisodique <\/strong>chez les adultes qui pr&eacute;sentent au moins 4 crises de migraine par mois. Le rim&eacute;g&eacute;pant n&#39;est pas rembours&eacute; en Belgique (situation au 01\/02\/2023&#x002C; pour le prix actuel <a href='https:\/\/www.cbip.be\/fr\/chapters\/11?frag=8903122'>voir le R&eacute;pertoire<\/a>).<\/p>\n<\/li>\n<li>\n<p>Une autre classe d&#39;antimigraineux qui agissent sur le CGRP ou son r&eacute;cepteur sont les anticorps monoclonaux anti-CGRP (uniquement en prophylaxie)&#x002C; dont trois sont actuellement commercialis&eacute;s en Belgique [voir <a href='https:\/\/www.cbip.be\/fr\/articles\/3662?folia=3658'>Folia d&rsquo;ao&ucirc;t 2021<\/a>]. Autre nouveaut&eacute; qui ne devrait pas tarder &agrave; appara&icirc;tre dans le paysage th&eacute;rapeutique belge&nbsp;: les agonistes des r&eacute;cepteurs 5HT<sub>1F<\/sub> pour le traitement de crise&#x002C; &eacute;galement appel&eacute;s les &laquo;&nbsp;ditans&nbsp;&raquo; <!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height: 150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family: 'Times New Roman';mso-ansi-language:FR-BE;mso-fareast-language:EN-US; mso-bidi-language:AR-SA\u2019><span style=\u2019mso-spacerun:yes\u2019>\u00a0<\/span>ADDIN EN.CITE <EndNote><Cite><Author>Schwarz<\/Author><Year>2022<\/Year><RecNum>26417<\/RecNum><DisplayText>\n\n<style face='superscript'>2<\/style>\n\n<\/DisplayText><record><rec-number>26417<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>26417<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>Schwarz&#x002C;E. P. <\/author><\/authors><\/contributors><titles><title>Nieuw geneesmiddel: rimegepant bij migraineaanvallen<\/title><secondary-title>Geneesmiddelenbulletin<\/secondary-title><\/titles><pages>65-8<\/pages><volume>8<\/volume><dates><year>2022<\/year><\/dates><urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=26417.pdf<\/url><\/pdf-urls><\/urls><access-date>2022\/08\/02 tot 2022\/08\/15<\/access-date><modified-date>H\u00b0 Psy; ISDB<\/modified-date><\/record><\/Cite><\/EndNote><\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>2<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]--> (autoris&eacute;s en Europe mais pas encore commercialis&eacute;s en Belgique).<\/p>\n<\/li>\n<li>\n<p>Outre le rim&eacute;g&eacute;pant&#x002C; deux <b>autres<\/b> &laquo;&nbsp;<b>g&eacute;pants&nbsp;&raquo; <\/b>ont &eacute;t&eacute; autoris&eacute;s<b> <\/b>aux Etats-Unis (situation au 01\/02\/2023) : l&#39;atog&eacute;pant pour la prophylaxie antimigraineuse et l&#39;ubrog&eacute;pant pour le traitement de la migraine aigu&euml;.<br \/> &nbsp;<\/p>\n<\/li>\n<\/ul>\n<h2>Efficacit&eacute; du rim&eacute;g&eacute;pant dans la migraine aigu&euml;<\/h2>\n<div class='summary'>Selon des &eacute;tudes randomis&eacute;es&#x002C; entre 19&nbsp;et&nbsp;31% des patients ne ressentent plus de douleur deux heures apr&egrave;s la prise de rim&eacute;g&eacute;pant&#x002C; soit 5 &agrave; 16 % de plus qu&#39;avec un placebo. Les &eacute;tudes incluaient principalement des femmes et l&#39;&acirc;ge moyen des participants &eacute;tait de 40 &agrave; 42 ans. Les patients avaient en moyenne 4 &agrave; 4&#x002C;6 crises de migraine par mois au d&eacute;but de l&#39;&eacute;tude. Les patients souffrant de maladies cardiovasculaires graves ou de troubles psychiatriques ont &eacute;t&eacute; exclus.<br \/> Des &eacute;tudes compl&eacute;mentaires sont n&eacute;cessaires pour savoir si le rim&eacute;g&eacute;pant garde son effet lorsqu&rsquo;il est utilis&eacute; de mani&egrave;re r&eacute;p&eacute;t&eacute;e pour des crises de migraine r&eacute;currentes.<br \/> La place du rim&eacute;g&eacute;pant dans l&rsquo;arsenal th&eacute;rapeutique de la crise de migraine reste incertaine pour l&#39;instant.<\/div>\n<h3>Le rim&eacute;g&eacute;pant en traitement de crise compar&eacute; au placebo<\/h3>\n<ul>\n<li>\n<p>Selon des <b>&eacute;tudes randomis&eacute;es <\/b>men&eacute;es sur un total de 4 700 patients (entre 2 et 8 crises de migraine par mois&#x002C; maximum 15 jours de c&eacute;phal&eacute;es par mois)&#x002C; <b>5 &agrave; 16% de patients suppl&eacute;mentaires <\/b>&eacute;taient <b>sans douleur <\/b>deux heures apr&egrave;s la prise de rim&eacute;g&eacute;pant 75 mg (entre 19&nbsp;et 31% sans douleur)&#x002C; par rapport au placebo. Le <b>sympt&ocirc;me le plus invalidant <\/b>(photophobie&#x002C; phonophobie&#x002C; naus&eacute;es ou vomissements) avait disparu au bout de 2 heures chez environ 1 patient sur 3&#x002C; contre environ 1 patient sur 4 sous placebo. (voir + Plus d&#39;infos &laquo; Le rim&eacute;g&eacute;pant en traitement de crise compar&eacute; &agrave; d&#39;autres m&eacute;dicaments &raquo;)<\/p>\n<\/li>\n<li>\n<p><b>Les participants &agrave; l&#39;&eacute;tude <\/b>&eacute;taient principalement des femmes (85 &agrave; 89%) et leur &acirc;ge moyen &eacute;tait de 40 &agrave; 42 ans. Les patients pouvaient &ecirc;tre sous prophylaxie antimigraineuse stable &agrave; condition que la prophylaxie ait &eacute;t&eacute; initi&eacute;e au moins 3 mois avant leur inclusion. Il n&#39;est pas pr&eacute;cis&eacute; combien de patients &eacute;taient effectivement sous r&eacute;gime prophylactique&nbsp;ni quel &eacute;tait le traitement m&eacute;dicamenteux utilis&eacute; dans ce cas-l&agrave;.<\/p>\n<\/li>\n<li>\n<p>Les patients souffrant d&rsquo;une <b>maladie cardiovasculaire <\/b>non contr&ocirc;l&eacute;e&#x002C; instable ou r&eacute;cemment diagnostiqu&eacute;e n&#39;ont pas &eacute;t&eacute; inclus dans les &eacute;tudes en raison du risque th&eacute;orique d&#39;un effet vasoconstricteur avec les inhibiteurs du CGRP. Ce crit&egrave;re d&#39;exclusion co&iuml;ncide largement avec les contre-indications aux triptans&#x002C; ce qui explique la faible proportion de sujets pr&eacute;sentant des contre-indications aux triptans dans les &eacute;tudes sur le rim&eacute;g&eacute;pant (0&#x002C;4 &agrave; 1&#x002C;2 %)<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height: 150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family: 'Times New Roman';mso-ansi-language:FR-BE;mso-fareast-language:EN-US; mso-bidi-language:AR-SA\u2019> ADDIN EN.CITE <EndNote><Cite><Author>EMA<\/Author><RecNum>26646<\/RecNum><DisplayText>\n\n<style face='superscript'>3<\/style>\n\n<\/DisplayText><record><rec-number>26646<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>26646<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>EMA&#x002C;<\/author><\/authors><\/contributors><titles><title>EPAR-Assessment Report Vydura\u00ae<\/title><\/titles><dates><\/dates><urls><related-urls><url>https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/vydura<\/url><\/related-urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=26646.pdf<\/url><\/pdf-urls><\/urls><\/record><\/Cite><\/EndNote><\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>3<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]-->. Autre crit&egrave;re d&rsquo;exclusion&nbsp;: les patients souffrant d&#39;une maladie h&eacute;patique existante et les patients ayant re&ccedil;u un diagnostic de d&eacute;pression majeure ou ayant d&#39;autres <b>troubles psychiatriques<\/b>.<\/p>\n<\/li>\n<li>\n<p>Nous n&#39;avons trouv&eacute; aucune &eacute;tude randomis&eacute;e ayant sp&eacute;cifiquement &eacute;valu&eacute; l&#39;effet du rim&eacute;g&eacute;pant en traitement de crise chez les patients <b>prenant d&eacute;j&agrave; du rim&eacute;g&eacute;pant &agrave; titre prophylactique ou recevant un autre traitement prophylactique<\/b>. Des rapports de cas sugg&egrave;rent que le rim&eacute;g&eacute;pant permet d&rsquo;att&eacute;nuer les crises de migraine chez les patients prenant des <b>anticorps monoclonaux <\/b>en prophylaxie<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height: 150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family: 'Times New Roman';mso-ansi-language:FR-BE;mso-fareast-language:EN-US; mso-bidi-language:AR-SA\u2019> ADDIN EN.CITE <\/span><span style=\u2019font-size:12.0pt; 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<\/xml><![endif]--><!--[if supportFields]><span style=\u2019font-size:12.0pt; line-height:150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family: 'Times New Roman';mso-ansi-language:NL-BE;mso-fareast-language:EN-US; mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-end\u2019><\/span><\/span><![endif]-->&#x002C; mais des recherches suppl&eacute;mentaires sont n&eacute;cessaires.<\/p>\n<\/li>\n<\/ul>\n<h3>Le rim&eacute;g&eacute;pant en traitement de crise compar&eacute; &agrave; d&#39;autres m&eacute;dicaments<\/h3>\n<ul>\n<li>\n<p>Les &eacute;tudes ayant &eacute;valu&eacute; l&#39;efficacit&eacute; du rim&eacute;g&eacute;pant <b>par rapport aux autres traitements de crise des migraines <\/b>sont rares :<\/p>\n<ul>\n<li>\n<p>La seule &eacute;tude&nbsp;<b>RCT comparative directe <\/b>&eacute;tait une &eacute;tude de &laquo;&nbsp;recherche de dose<i>&nbsp;&raquo; <\/i>ayant &eacute;valu&eacute; une administration unique de rim&eacute;g&eacute;pant (&agrave; diff&eacute;rentes doses)&#x002C; de <b>sumatriptan 100 mg <\/b>ou d&rsquo;un placebo<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span><span style=\u2019mso-bookmark:_Hlk130282348\u2019> ADDIN EN.CITE <\/span><span style=\u2019mso-element:field-begin\u2019><\/span><span style=\u2019mso-bookmark:_Hlk130282348\u2019><span style=\u2019mso-spacerun:yes\u2019>\u00a0<\/span>ADDIN EN.CITE.DATA <![if gte mso 9]><xml> 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<\/xml><![endif]--><!--[if supportFields]><span style=\u2019font-size: 12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font: minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin; mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE;mso-fareast-language: EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-end\u2019><\/span><\/span><![endif]-->. Par rapport au placebo&#x002C; le taux de r&eacute;ponse semblait l&eacute;g&egrave;rement meilleur avec le sumatriptan 100 mg (35% des patients sans douleur apr&egrave;s 2 heures) qu&#39;avec le rim&eacute;g&eacute;pant 75 mg (31&#x002C;4% sans douleur)&#x002C; mais il n&#39;y a pas eu de test statistique pour la comparaison rim&eacute;g&eacute;pant versus sumatriptan. Le rim&eacute;g&eacute;pant et le sumatriptan &eacute;taient tous deux plus efficaces que le placebo (15&#x002C;3 % de personnes sans douleur apr&egrave;s 2 heures) (voir + Plus d&#39;infos).<\/p>\n<\/li>\n<li>\n<p>Une <b>m&eacute;ta-analyse en r&eacute;seau<\/b> de plusieurs RCT en double aveugle concluait que le rim&eacute;g&eacute;pant &eacute;tait moins efficace que la plupart des triptans&#x002C; mais cette conclusion &eacute;tait seulement bas&eacute;e sur des comparaisons indirectes et&#x002C; selon les auteurs de la m&eacute;ta-analyse&#x002C; il y avait un biais de publication<!--[if supportFields]><sup><span lang=FR-BE style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:FR-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span> ADDIN EN.CITE <span style=\u2019mso-element:field-begin\u2019><\/span><span style=\u2019mso-spacerun:yes\u2019>\u00a0<\/span>ADDIN EN.CITE.DATA <![if gte mso 9]><xml> <\/xml><![endif]><span style=\u2019mso-element:field-end\u2019><\/span><span style=\u2019mso-element:field-separator\u2019><\/span><\/span><\/sup><![endif]--><span class='folia-referentie-nummer'><sup>2&#x002C; 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mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:FR-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><\/sup><![endif]-->. En outre&#x002C; les populations ne sont pas tout &agrave; fait comparables. (voir + Plus d&#39;infos)<\/p>\n<\/li>\n<li>\n<div class='detailed-content'>\n<ul>\n<li>Via nos sources&#x002C; nous avons trouv&eacute; les RCT suivantes sur le rim&eacute;g&eacute;pant en traitement de crise :<br \/> &nbsp; &nbsp; &nbsp;&#8211;&nbsp;Une &eacute;tude de &quot;recherche de dose&quot; de phase II ayant randomis&eacute; les patients sur une<br \/> &nbsp; &nbsp; &nbsp; &nbsp;administration unique de rim&eacute;g&eacute;pant (doses de 10 &agrave; 600 mg)&#x002C; de sumatriptan 100 mg et un<br \/> &nbsp; &nbsp; &nbsp; &nbsp;placebo<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span><span style=\u2019mso-bookmark:_Hlk130282415\u2019> ADDIN EN.CITE <EndNote><Cite><Author>Marcus<\/Author><Year>2014<\/Year><RecNum>27254<\/RecNum><DisplayText>\n\n<style face='superscript'>7<\/style>\n\n<\/DisplayText><record><rec-number>27254<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>27254<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>Marcus&#x002C;Ronald<\/author><author>Goadsby&#x002C;Peter J<\/author><author>Dodick&#x002C;David<\/author><author>Stock&#x002C;David<\/author><author>Manos&#x002C;George<\/author><author>Fischer&#x002C;Tanya Z<\/author><\/authors><\/contributors><auth-address>Bristol-Myers Squibb&#x002C; Wallingford&#x002C; CT&#x002C; USA.<\/auth-address><titles><title>BMS-927711 for the acute treatment of migraine: a double-blind&#x002C; randomized&#x002C; placebo controlled&#x002C; dose-ranging trial.<\/title><secondary-title>Cephalalgia<\/secondary-title><\/titles><pages>114-25<\/pages><volume>34<\/volume><number>2<\/number><dates><year>2014<\/year><\/dates><urls><related-urls><url>https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23965396<\/url><\/related-urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=27254.pdf<\/url><\/pdf-urls><\/urls><electronic-resource-num>10.1177\/0333102413500727<\/electronic-resource-num><\/record><\/Cite><\/EndNote><span style=\u2019mso-element:field-separator\u2019><\/span><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>7<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]-->.<br \/> &nbsp; &nbsp; &nbsp;&#8211;&nbsp;Trois &eacute;tudes de phase III ayant compar&eacute; une administration unique de rim&eacute;g&eacute;pant 75 mg &agrave;<br \/> &nbsp; &nbsp; &nbsp; &nbsp;un&nbsp;placebo<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span><span style=\u2019mso-bookmark:_Hlk130282441\u2019> ADDIN EN.CITE <\/span><span style=\u2019mso-element:field-begin\u2019><\/span><span style=\u2019mso-bookmark:_Hlk130282441\u2019><span style=\u2019mso-spacerun:yes\u2019>\u00a0<\/span>ADDIN EN.CITE.DATA <![if gte mso 9]><xml> 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<\/xml><![endif]--><!--[if supportFields]><span style=\u2019font-size: 12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font: minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin; mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE;mso-fareast-language: NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-end\u2019><\/span><\/span><![endif]-->.\n<p> &nbsp; &nbsp; &nbsp;Toutes les &eacute;tudes incluaient des adultes souffrant de migraine avec ou sans aura&#x002C; ayant 2 &agrave; 8<br \/> &nbsp; &nbsp; &nbsp;crises de migraine par mois (en moyenne 4 &agrave; 4&#x002C;6) et moins de 15 jours de c&eacute;phal&eacute;es par mois.<br \/> &nbsp;<br \/> Crit&egrave;res d&#39;&eacute;valuation primaires :<br \/> &nbsp; &nbsp; &nbsp;&#8211;&nbsp;Pourcentage de patients sans douleur 2 heures apr&egrave;s la prise ;<br \/> &nbsp; &nbsp; &nbsp;&#8211;&nbsp;Pourcentage de patients dont le sympt&ocirc;me migraineux le plus invalidant (naus&eacute;e&#x002C;<br \/> &nbsp; &nbsp; &nbsp; &nbsp;vomissement&#x002C; photophobie ou phonophobie) avait disparu 2 heures apr&egrave;s la prise du<br \/> &nbsp; &nbsp; &nbsp; &nbsp;m&eacute;dicament.<\/li>\n<\/ul>\n<p> Tableau : &eacute;tudes randomis&eacute;es contr&ocirc;l&eacute;es par placebo avec le rim&eacute;g&eacute;pant en traitement de crise des migraines<br \/> &nbsp; <\/p>\n<table border='1' cellpadding='1' cellspacing='1' style='width:600px;'>\n<tbody>\n<tr>\n<td>&Eacute;tude<\/td>\n<td>Intervention<\/td>\n<td>Crit&egrave;res d&#39;&eacute;valuation cliniques<\/td>\n<td>R&eacute;sultat<\/td>\n<\/tr>\n<tr>\n<td>RCT de &quot;recherche de dose&quot; aupr&egrave;s de 886 adultes pr&eacute;sentant 2 &agrave; 7 crises de migraine par mois<span class='folia-referentie-nummer'><sup>7<\/sup><\/span><\/td>\n<td>Rim&eacute;g&eacute;pant 10-600&nbsp;mg vs.<br \/> sumatriptan 100 mg vs. placebo<\/td>\n<td>Disparition de la douleur apr&egrave;s 2h<br \/> (92% ont termin&eacute; l&#39;&eacute;tude)<\/td>\n<td>Rim&eacute;g&eacute;pant<br \/> 75 mg : 31&#x002C;4%<br \/> 150 mg : 32&#x002C;9%<br \/> 300 mg : 29&#x002C;7%<br \/> (p&lt;0&#x002C;05 vs. placebo)<br \/> &nbsp;<br \/> Sumatriptan 35%<br \/> (p&lt;0&#x002C;05 vs. placebo)<br \/> &nbsp;<br \/> Placebo 15&#x002C;3%<\/td>\n<\/tr>\n<tr>\n<td>RCT aupr&egrave;s de 1 186 adultes pr&eacute;sentant 2 &agrave; 8 crises de migraine par mois<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span> ADDIN EN.CITE <EndNote><Cite><Author>Lipton<\/Author><Year>2019<\/Year><RecNum>19361<\/RecNum><DisplayText>\n\n<style face='superscript'>9<\/style>\n\n<\/DisplayText><record><rec-number>19361<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>19361<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>Lipton&#x002C;R. B. <\/author><author>Croop&#x002C;R. <\/author><author>Stock&#x002C;E. G. <\/author><author>Stock&#x002C;D. A. <\/author><author>Morris&#x002C;B. A. <\/author><author>Frost&#x002C;M. <\/author><author>Dubowchik&#x002C;G. M. <\/author><author>Conway&#x002C;C. M. <\/author><author>Coric&#x002C;V. <\/author><author>Goadsby&#x002C;P. J. <\/author><\/authors><\/contributors><auth-address>From the Departments of Neurology and Epidemiology and Population Health&#x002C; Albert Einstein College of Medicine&#x002C; and Montefiore Medical Center - both in Bronx&#x002C; NY (R.B.L.); Biohaven Pharmaceuticals&#x002C; New Haven&#x002C; CT (R.C.&#x002C; E.G.S.&#x002C; D.A.S.&#x002C; B.A.M.&#x002C; M.F.&#x002C; G.M.D.&#x002C; C.M.C.&#x002C; V.C.); NIHR-Wellcome Trust King&apos;s Clinical Research Facility&#x002C; King&apos;s College Hospital-South London and Maudsley Biomedical Research Centre&#x002C; King&apos;s College London&#x002C; London (P.J.G.); and the University of California&#x002C; San Francisco&#x002C; San Francisco (P.J.G.).<\/auth-address><titles><title>Rimegepant&#x002C; an oral calcitonin gene-related peptide receptor antagonist&#x002C; for migraine<\/title><secondary-title>N Engl J Med<\/secondary-title><\/titles><pages>142-149<\/pages><volume>381<\/volume><number>2<\/number><dates><year>2019<\/year><\/dates><urls><related-urls><url>https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31291516<\/url><\/related-urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=19361.pdf<\/url><\/pdf-urls><\/urls><electronic-resource-num>10.1056\/NEJMoa1811090<\/electronic-resource-num><access-date>2019-08-15<\/access-date><modified-date>H\u00b0 Zen; H\u00b0 Pijn; TF Mig<\/modified-date><\/record><\/Cite><\/EndNote><span style=\u2019mso-element:field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>9<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]--><\/td>\n<td>Rim&eacute;g&eacute;pant<br \/> 75 mg vs. placebo<br \/> (administration unique)<\/td>\n<td>Disparition de la douleur apr&egrave;s 2h<br \/> (90% ont termin&eacute; l&#39;&eacute;tude)<\/p>\n<p> Disparition du sympt&ocirc;me le plus invalidant apr&egrave;s 2&nbsp;h<\/td>\n<td>19&#x002C;6% contre 12%<br \/> Diff&eacute;rence de 7&#x002C;6% (IC &agrave; 95% de 3&#x002C;3 &agrave; 11&#x002C;9)<\/p>\n<p> 37&#x002C;6% contre 25&#x002C;2%<br \/> Diff&eacute;rence de 12&#x002C;4% (IC &agrave; 95% de 6&#x002C;9 &agrave; 17&#x002C;9)<\/p>\n<p> &nbsp;<\/td>\n<\/tr>\n<tr>\n<td>RCT aupr&egrave;s de 1 466 adultes pr&eacute;sentant 2 &agrave; 8 crises de migraine par mois<!--[if supportFields]><span style=\u2019font-size:12.0pt; line-height:150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family: 'Times New Roman';mso-ansi-language:NL-BE;mso-fareast-language:NL-BE; mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:FR-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019> ADDIN EN.CITE <EndNote><Cite><Author>Lipton<\/Author><Year>2019<\/Year><RecNum>19361<\/RecNum><DisplayText>\n\n<style face='superscript'>9<\/style>\n\n<\/DisplayText><record><rec-number>19361<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>19361<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>Lipton&#x002C;R. B. <\/author><author>Croop&#x002C;R. <\/author><author>Stock&#x002C;E. G. <\/author><author>Stock&#x002C;D. A. <\/author><author>Morris&#x002C;B. A. <\/author><author>Frost&#x002C;M. <\/author><author>Dubowchik&#x002C;G. M. <\/author><author>Conway&#x002C;C. M. <\/author><author>Coric&#x002C;V. <\/author><author>Goadsby&#x002C;P. J. <\/author><\/authors><\/contributors><auth-address>From the Departments of Neurology and Epidemiology and Population Health&#x002C; Albert Einstein College of Medicine&#x002C; and Montefiore Medical Center - both in Bronx&#x002C; NY (R.B.L.); Biohaven Pharmaceuticals&#x002C; New Haven&#x002C; CT (R.C.&#x002C; E.G.S.&#x002C; D.A.S.&#x002C; B.A.M.&#x002C; M.F.&#x002C; G.M.D.&#x002C; C.M.C.&#x002C; V.C.); NIHR-Wellcome Trust King&apos;s Clinical Research Facility&#x002C; King&apos;s College Hospital-South London and Maudsley Biomedical Research Centre&#x002C; King&apos;s College London&#x002C; London (P.J.G.); and the University of California&#x002C; San Francisco&#x002C; San Francisco (P.J.G.).<\/auth-address><titles><title>Rimegepant&#x002C; an oral calcitonin gene-related peptide receptor antagonist&#x002C; for migraine<\/title><secondary-title>N Engl J Med<\/secondary-title><\/titles><pages>142-149<\/pages><volume>381<\/volume><number>2<\/number><dates><year>2019<\/year><\/dates><urls><related-urls><url>https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31291516<\/url><\/related-urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=19361.pdf<\/url><\/pdf-urls><\/urls><electronic-resource-num>10.1056\/NEJMoa1811090<\/electronic-resource-num><access-date>2019-08-15<\/access-date><modified-date>H\u00b0 Zen; H\u00b0 Pijn; TF Mig<\/modified-date><\/record><\/Cite><\/EndNote><\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>9<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]--><\/td>\n<td>Rim&eacute;g&eacute;pant<br \/> 75 mg vs. placebo<\/td>\n<td>Disparition de la douleur apr&egrave;s 2&nbsp;h<br \/> (92% ont termin&eacute; l&#39;&eacute;tude)<\/p>\n<p> Disparition du sympt&ocirc;me le plus invalidant apr&egrave;s 2&nbsp;h<\/td>\n<td>21&#x002C;2% contre 10&#x002C;9%<br \/> Diff&eacute;rence de 10&#x002C;4% (IC &agrave; 95% de 6&#x002C;5 &agrave; 14&#x002C;2)<\/p>\n<p> 35&#x002C;1% contre 26&#x002C;8%<br \/> Diff&eacute;rence de 8&#x002C;3% (IC &agrave; 95% de 3&#x002C;4 &agrave; 13&#x002C;2)<\/td>\n<\/tr>\n<tr>\n<td>RCT aupr&egrave;s de 1 162 adultes pr&eacute;sentant 2 &agrave; 8 crises de migraine par mois<sup><span class='folia-referentie-nummer'>3<\/span><\/sup>&#x002C; <a href='https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03235479'>BHV3000-301<\/a><br \/> (pas encore examin&eacute;e par des pairs)<\/td>\n<td>Rim&eacute;g&eacute;pant<br \/> 75 mg vs placebo<\/td>\n<td>Disparition de la douleur apr&egrave;s 2&nbsp;h<br \/> (93% ont termin&eacute; l&#39;&eacute;tude)<\/p>\n<p> Disparition du sympt&ocirc;me le plus invalidant apr&egrave;s 2&nbsp;h<\/td>\n<td>19&#x002C;2% contre 14&#x002C;2%<br \/> Diff&eacute;rence de 4&#x002C;9% (IC &agrave; 95% de 0&#x002C;5 &agrave; 9&#x002C;3)<\/p>\n<p> 36&#x002C;6% contre 27&#x002C;7%<br \/> Diff&eacute;rence de 8&#x002C;9% (IC &agrave; 95% de 3&#x002C;4 &agrave; 14&#x002C;4)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p> &nbsp; <\/p>\n<ul>\n<li>Une m&eacute;ta-analyse publi&eacute;e dans le JAMA<sup><span class='folia-referentie-nummer'>11<\/span><\/sup> incluait uniquement des &eacute;tudes publi&eacute;es. Selon cette m&eacute;ta-analyse&#x002C; la probabilit&eacute; d&rsquo;&ecirc;tre sans douleur apr&egrave;s deux heures &eacute;tait plus grande avec le rim&eacute;g&eacute;pant qu&#39;avec le placebo (RR 1&#x002C;80 (IC &agrave; 95% 1&#x002C;52 &agrave; 2&#x002C;13)&#x002C; diff&eacute;rence de risque de 0&#x002C;09 (IC &agrave; 95% de 0&#x002C;06 &agrave; 0&#x002C;11)&#x002C; niveau de preuve mod&eacute;r&eacute;).<\/li>\n<li>Un article de synth&egrave;se de Cohen<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height: 150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family: 'Times New Roman';mso-ansi-language:FR-BE;mso-fareast-language:NL-BE; mso-bidi-language:AR-SA\u2019> ADDIN EN.CITE <EndNote><Cite><Author>Cohen<\/Author><Year>2022<\/Year><RecNum>27249<\/RecNum><DisplayText>\n\n<style face='superscript'>6<\/style>\n\n<\/DisplayText><record><rec-number>27249<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>27249<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>Cohen&#x002C;Fred<\/author><author>Yuan&#x002C;Hsiangkuo<\/author><author>Silberstein&#x002C;Stephen D<\/author><\/authors><\/contributors><auth-address>Jefferson Headache Center&#x002C; Department of Neurology&#x002C; Thomas Jefferson University&#x002C; 900 Walnut Street&#x002C; Suite 200&#x002C; Philadelphia&#x002C; PA&#x002C; 19107&#x002C; USA.<\/auth-address><titles><title>Calcitonin Gene-Related Peptide (CGRP)-targeted monoclonal antibodies and antagonists in migraine: current evidence and rationale.<\/title><secondary-title>BioDrugs<\/secondary-title><\/titles><pages>341-358<\/pages><volume>36<\/volume><number>3<\/number><dates><year>2022<\/year><\/dates><urls><related-urls><url>https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35476215<\/url><\/related-urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=27249.pdf<\/url><\/pdf-urls><\/urls><electronic-resource-num>10.1007\/s40259-022-00530-0<\/electronic-resource-num><\/record><\/Cite><\/EndNote><\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>6<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]--> sur le rim&eacute;g&eacute;pant&#x002C; cit&eacute; dans le <i>Geneesmiddelenbulletin<\/i><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height: 150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family: 'Times New Roman';mso-ansi-language:FR-BE;mso-fareast-language:NL-BE; mso-bidi-language:AR-SA\u2019> ADDIN EN.CITE <EndNote><Cite><Author>Schwarz<\/Author><Year>2022<\/Year><RecNum>26417<\/RecNum><DisplayText>\n\n<style face='superscript'>2<\/style>\n\n<\/DisplayText><record><rec-number>26417<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>26417<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>Schwarz&#x002C;E. P. <\/author><\/authors><\/contributors><titles><title>Nieuw geneesmiddel: rimegepant bij migraineaanvallen<\/title><secondary-title>Geneesmiddelenbulletin<\/secondary-title><\/titles><pages>65-8<\/pages><volume>8<\/volume><dates><year>2022<\/year><\/dates><urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=26417.pdf<\/url><\/pdf-urls><\/urls><access-date>2022\/08\/02 tot 2022\/08\/15<\/access-date><modified-date>H\u00b0 Psy; ISDB<\/modified-date><\/record><\/Cite><\/EndNote><\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>2<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]-->&#x002C; fait r&eacute;f&eacute;rence &agrave; une autre m&eacute;ta-analyse<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height: 150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family: 'Times New Roman';mso-ansi-language:FR-BE;mso-fareast-language:NL-BE; mso-bidi-language:AR-SA\u2019> ADDIN EN.CITE <EndNote><Cite><Author>Gao<\/Author><Year>2020<\/Year><RecNum>27460<\/RecNum><DisplayText>\n\n<style face='superscript'>12<\/style>\n\n<\/DisplayText><record><rec-number>27460<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>27460<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>Gao&#x002C;Bixi<\/author><author>Yang&#x002C;Yanbo<\/author><author>Wang&#x002C;Zilan<\/author><author>Sun&#x002C;Yue<\/author><author>Chen&#x002C;Zhouqing<\/author><author>Zhu&#x002C;Yun<\/author><author>Wang&#x002C;Zhong<\/author><\/authors><\/contributors><auth-address>Department of Neurosurgery & Brain and Nerve Research Laboratory&#x002C; The First Affiliated Hospital of Soochow University&#x002C; Suzhou&#x002C; China.<\/auth-address><titles><title>Efficacy and safety of rimegepant for the acute treatment of migraine: evidence from randomized controlled trials.<\/title><secondary-title>Front Pharmacol<\/secondary-title><\/titles><pages>1577<\/pages><volume>10<\/volume><dates><year>2020<\/year><\/dates><urls><related-urls><url>https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32038251<\/url><\/related-urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=27460.pdf<\/url><\/pdf-urls><\/urls><electronic-resource-num>10.3389\/fphar.2019.01577<\/electronic-resource-num><\/record><\/Cite><\/EndNote><\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>12<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]-->&#x002C; qui inclut &eacute;galement les donn&eacute;es d&#39;une &eacute;tude non publi&eacute;e. Les r&eacute;sultats de cette m&eacute;ta-analyse sont comparables aux r&eacute;sultats de la m&eacute;ta-analyse publi&eacute;e dans le JAMA.<\/li>\n<li>Selon <a href='https:\/\/www.minerva-ebp.be\/Home\/Glossary?alpha=m#glossaryId20'>une m&eacute;ta-analyse en r&eacute;seau<\/a> portant uniquement sur des comparaisons indirectes<span class='folia-referentie-nummer'><sup>8<\/sup><\/span>&#x002C; la plupart des triptans sont associ&eacute;s &agrave; une plus grande probabilit&eacute; de disparition des douleurs dans les deux heures que le rim&eacute;g&eacute;pant (rapport de cotes (odds ratio) de 1&#x002C;58 (IC &agrave; 95% de 1&#x002C;07 &agrave; 2&#x002C;33) &agrave; 3&#x002C;13 (IC &agrave; 95% de 2&#x002C;16 &agrave; 4&#x002C;52)). Mais les populations &eacute;tudi&eacute;es ne sont pas tout &agrave; fait comparables. Une <em>Cochrane Review<\/em><span class='folia-referentie-nummer'><sup>13<\/sup><\/span> nous apprend par exemple que la plupart des &eacute;tudes sur le sumatriptan oral incluaient des patients ayant en moyenne 1 &agrave; 6 crises par mois. Dans les &eacute;tudes sur le rim&eacute;g&eacute;pant&#x002C; les patients inclus avaient en moyenne 2 &agrave; 8 crises de migraine par mois.<\/li>\n<\/ul><\/div>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<p>On ne dispose pas encore d&#39;&eacute;tudes publi&eacute;es sur l&#39;efficacit&eacute; et la s&eacute;curit&eacute; du rim&eacute;g&eacute;pant <b>chez les patients ne r&eacute;pondant pas ou pr&eacute;sentant des contre-indications aux autres traitements de crise<\/b>. Le rim&eacute;g&eacute;pant pourrait &ecirc;tre une alternative pour les patients ne r&eacute;pondant pas aux triptans. Une &eacute;tude a toutefois &eacute;t&eacute; lanc&eacute;e r&eacute;cemment pour &eacute;valuer l&rsquo;efficacit&eacute; et la s&eacute;curit&eacute; du rim&eacute;g&eacute;pant chez des patients migraineux non &eacute;ligibles aux triptans [<a href='https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT05509400'>Clinicaltrials.gov<\/a>].<\/p>\n<\/li>\n<li>\n<p>On sait que les triptans et les antalgiques sont susceptibles de provoquer une aggravation de la migraine et des c&eacute;phal&eacute;es chroniques quotidiennes en cas de surconsommation<span class='folia-referentie-nummer'><sup>14<\/sup><\/span>. &Agrave; l&rsquo;heure actuelle&#x002C; ce risque ne peut &ecirc;tre exclu pour le rim&eacute;g&eacute;pant en raison des donn&eacute;es insuffisantes.<\/p>\n<\/li>\n<\/ul>\n<h3>Les effets &agrave; long terme du rim&eacute;g&eacute;pant en traitement de crise<\/h3>\n<ul>\n<li>\n<p>Toutes les &eacute;tudes randomis&eacute;es ayant &eacute;valu&eacute; l&#39;effet du rim&eacute;g&eacute;pant en traitement de crise portaient sur une administration unique. La question est de savoir si l&#39;effet est maintenu lorsque le rim&eacute;g&eacute;pant est utilis&eacute; de fa&ccedil;on r&eacute;p&eacute;t&eacute;e dans les crises de migraine r&eacute;currentes<!--[if supportFields]><span style=\u2019font-size: 12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font: minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin; mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE;mso-fareast-language: NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-begin\u2019><\/span><span style=\u2019mso-bookmark:_Hlk130283489\u2019> ADDIN EN.CITE <EndNote><Cite><Author>Schwarz<\/Author><Year>2022<\/Year><RecNum>26417<\/RecNum><DisplayText>\n\n<style face='superscript'>2<\/style>\n\n<\/DisplayText><record><rec-number>26417<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>26417<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>Schwarz&#x002C;E. P. <\/author><\/authors><\/contributors><titles><title>Nieuw geneesmiddel: rimegepant bij migraineaanvallen<\/title><secondary-title>Geneesmiddelenbulletin<\/secondary-title><\/titles><pages>65-8<\/pages><volume>8<\/volume><dates><year>2022<\/year><\/dates><urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=26417.pdf<\/url><\/pdf-urls><\/urls><access-date>2022\/08\/02 tot 2022\/08\/15<\/access-date><modified-date>H\u00b0 Psy; ISDB<\/modified-date><\/record><\/Cite><\/EndNote><span style=\u2019mso-element:field-separator\u2019><\/span><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>2<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]-->.<\/p>\n<\/li>\n<li>\n<p>Selon une <b>analyse <i>a posteriori<\/i> <\/b>des donn&eacute;es d&#39;une <b>&eacute;tude de s&eacute;curit&eacute; ouverte<\/b>&#x002C; le rim&eacute;g&eacute;pant &eacute;tait toujours efficace apr&egrave;s un an&#x002C; utilis&eacute; &laquo;&nbsp;selon les besoins&nbsp;&raquo; <!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height: 150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; 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style=\u2019mso-spacerun:yes\u2019>\u00a0<\/span>ADDIN EN.CITE.DATA <\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family: 'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin;mso-fareast-font-family: Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:'Times New Roman'; mso-ansi-language:NL-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><![if gte mso 9]><xml> 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<\/xml><![endif]--><!--[if supportFields]><span style=\u2019font-size:12.0pt; line-height:150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family: 'Times New Roman';mso-ansi-language:NL-BE;mso-fareast-language:NL-BE; mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-end\u2019><\/span><\/span><![endif]-->. L&rsquo;&eacute;tude avait toutefois un taux d&rsquo;abandon &eacute;lev&eacute; (environ 4 patients sur 10&#x002C; raison non pr&eacute;cis&eacute;e)&#x002C; ce qui complique l&#39;interpr&eacute;tation des r&eacute;sultats. Des recherches suppl&eacute;mentaires sont n&eacute;cessaires.<br \/> &nbsp;<\/p>\n<\/li>\n<\/ul>\n<h2>Efficacit&eacute; du rim&eacute;g&eacute;pant en prophylaxie antimigraineuse<\/h2>\n<div class='summary'>Les patients ayant en moyenne 10 jours de migraine par mois&#x002C; ont en moyenne 0&#x002C;8 jours de migraine en moins au cours du troisi&egrave;me mois suivant le d&eacute;but de la prise prophylactique de rim&eacute;g&eacute;pant (tous les deux jours)&#x002C; par rapport au placebo.<br \/> Pr&egrave;s de la moiti&eacute; des patients rapportent une r&eacute;duction d&#39;au moins 50% du nombre de jours de migraine mod&eacute;r&eacute;e &agrave; s&eacute;v&egrave;re par mois avec le rim&eacute;g&eacute;pant&#x002C; contre 41% patients avec le placebo. On ignore actuellement si le b&eacute;n&eacute;fice est maintenu en cas de traitement durant plus de 3 mois.<br \/> \u200bDes &eacute;tudes comparatives directes avec d&#39;autres antimigraineux prophylactiques sont n&eacute;cessaires pour mieux cerner la place du rim&eacute;g&eacute;pant au sein de l&#39;arsenal th&eacute;rapeutique. Des &eacute;tudes sont &eacute;galement n&eacute;cessaires pour &eacute;valuer l&#39;utilit&eacute; d&rsquo;une prophylaxie au rim&eacute;g&eacute;pant chez les patients ayant &eacute;chou&eacute; &agrave; d&#39;autres traitements prophylactiques antimigraineux.<\/div>\n<h3>Le rim&eacute;g&eacute;pant en prophylaxie compar&eacute; au placebo<\/h3>\n<ul>\n<li>\n<p>Dans une &eacute;tude randomis&eacute;e<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height: 150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family: 'Times New Roman';mso-ansi-language:FR-BE;mso-fareast-language:EN-US; mso-bidi-language:AR-SA\u2019> ADDIN EN.CITE <EndNote><Cite><Author>Croop<\/Author><Year>2021<\/Year><RecNum>22563<\/RecNum><DisplayText>\n\n<style face='superscript'>16<\/style>\n\n<\/DisplayText><record><rec-number>22563<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>22563<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>Croop&#x002C;R. <\/author><author>Lipton&#x002C;R. B. <\/author><author>Kudrow&#x002C;D. <\/author><author>Stock&#x002C;D. A. <\/author><author>Kamen&#x002C;L. <\/author><author>Conway&#x002C;C. M. <\/author><author>Stock&#x002C;E. G. <\/author><author>Coric&#x002C;V. <\/author><author>Goadsby&#x002C;P. J. <\/author><\/authors><\/contributors><auth-address>Biohaven Pharmaceuticals&#x002C; New Haven&#x002C; CT&#x002C; USA. Electronic address: robert.croop@biohavenpharma.com. Department of Neurology&#x002C; Albert Einstein College of Medicine&#x002C; Bronx&#x002C; NY&#x002C; USA. California Medical Clinic for Headache&#x002C; Santa Monica&#x002C; CA&#x002C; USA. Biohaven Pharmaceuticals&#x002C; New Haven&#x002C; CT&#x002C; USA. NIHR-Wellcome Trust King&apos;s Clinical Research Facility&#x002C; King&apos;s College Hospital\/SLaM Biomedical Research Centre&#x002C; King&apos;s College London&#x002C; UK; University of California&#x002C; Los Angeles&#x002C; Los Angeles&#x002C; CA&#x002C; USA.<\/auth-address><titles><title>Oral rimegepant for preventive treatment of migraine: a phase 2\/3&#x002C; randomised&#x002C; double-blind&#x002C; placebo-controlled trial<\/title><secondary-title>Lancet<\/secondary-title><\/titles><pages>51-60<\/pages><volume>397<\/volume><number>10268<\/number><dates><year>2021<\/year><\/dates><urls><related-urls><url>https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33338437<\/url><\/related-urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=22563.pdf<\/url><\/pdf-urls><\/urls><electronic-resource-num>10.1016\/S0140-6736(20)32544-7<\/electronic-resource-num><access-date>2021\/01\/02 tot 2021\/01\/15<\/access-date><modified-date>H\u00b0 Zen; TF Mig<\/modified-date><\/record><\/Cite><\/EndNote><\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>16<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]-->&#x002C; la <b>prise prophylactique <\/b>de rim&eacute;g&eacute;pant 75 mg (tous les deux jours) par des patients <b>migraineux <\/b>(83% de femmes&#x002C; &acirc;ge moyen de 41 ans&#x002C; en moyenne 10&nbsp;jours de migraine par mois &agrave; l&rsquo;inclusion) a entra&icirc;n&eacute; une diminution des jours de migraine d&rsquo;en moyenne 0&#x002C;8 jour dans le troisi&egrave;me mois suivant le d&eacute;but de la prise&#x002C; par rapport au placebo. Avec le rim&eacute;g&eacute;pant&#x002C; le nombre de jours de migraine avait diminu&eacute; en moyenne de 4&#x002C;3&#x002C; contre 3&#x002C;5 jours en moyenne avec le placebo. Le nombre de jours de migraine mod&eacute;r&eacute;e &agrave; s&eacute;v&egrave;re par mois avait diminu&eacute; d&#39;au moins la moiti&eacute; chez 49% des patients&#x002C; contre 41% des patients sous placebo.<\/p>\n<\/li>\n<li>\n<p>L&rsquo;&eacute;tude incluait trop peu de patients souffrant de migraine chronique pour pouvoir se prononcer sur l&#39;effet du rim&eacute;g&eacute;pant dans ce sous-groupe. C&rsquo;est pourquoi l&#39;indication dans le RCP a &eacute;t&eacute; limit&eacute;e &agrave; la <b>migraine &eacute;pisodique<\/b>.<\/p>\n<\/li>\n<li>\n<p>Il n&#39;existe pas de donn&eacute;es sur l&#39;efficacit&eacute; du <b>rim&eacute;g&eacute;pant utilis&eacute; en aigu<\/b> chez les patients qui en prennent d&eacute;j&agrave; &agrave; titre prophylactique. Dans l&#39;&eacute;tude sur la prophylaxie&#x002C; le recours au rim&eacute;g&eacute;pant en traitement de crise n&#39;&eacute;tait pas autoris&eacute;.<\/p>\n<\/li>\n<li>\n<p><er de='' geen='' gegevens='' over='' van='' werkzaamheid='' zijn=''>R&eacute;cemment&#x002C;&nbsp;une RCT a &eacute;t&eacute; lanc&eacute;e pour &eacute;valuer le rim&eacute;g&eacute;pant chez des <strong><a href='https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05518123'>patients n&rsquo;ayant pas r&eacute;pondu &agrave; d&#39;autres traitements prophylactiques <\/a>antimigraineux par voie orale<\/strong>.<\/er><\/p>\n<\/li>\n<\/ul>\n<div class='detailed-content'>L&#39;&eacute;tude ayant &eacute;valu&eacute; le rim&eacute;g&eacute;pant en prophylaxie incluait des adultes souffrant de migraine avec aura (40%) ou sans aura (60%). 23% des participants avaient des ant&eacute;c&eacute;dents de migraine chronique.<br \/> Les patients devaient avoir au moins 4 et maximum 18 crises de migraine mod&eacute;r&eacute;es &agrave; s&eacute;v&egrave;res par mois et avoir connu au moins 6 jours de migraine dans le mois pr&eacute;c&eacute;dant la randomisation.<\/p>\n<p> Tableau : &eacute;tudes randomis&eacute;es avec le rim&eacute;g&eacute;pant en prophylaxie antimigraineuse<br \/> &nbsp; <\/p>\n<table border='1' cellpadding='1' cellspacing='1' style='width:600px;'>\n<tbody>\n<tr>\n<td>&Eacute;tude<\/td>\n<td>Interventions<\/td>\n<td>Crit&egrave;res d&#39;&eacute;valuation cliniques<\/td>\n<td>R&eacute;sultats<\/td>\n<\/tr>\n<tr>\n<td>RCT aupr&egrave;s de 747 adultes ayant en moyenne 10&nbsp;jours de migraine par mois<span class='folia-referentie-nummer'><sup>16<\/sup><\/span><\/td>\n<td>Rim&eacute;g&eacute;pant 75 mg tous les deux jours vs. placebo<\/p>\n<p> Dur&eacute;e du traitement: 3&nbsp;mois (84% ont termin&eacute; le traitement&#x002C; 93% ont &eacute;t&eacute; inclus dans l&#39;analyse pour le crit&egrave;re d&rsquo;&eacute;valuation primaire)<\/td>\n<td>Variation du nombre de jours de migraine par mois (crit&egrave;re d&rsquo;&eacute;valuation primaire)<\/p>\n<p> Pourcentage de patients pr&eacute;sentant une r&eacute;duction d&#39;au moins 50% du nombre de jours de migraine mod&eacute;r&eacute;e &agrave; s&eacute;v&egrave;re (crit&egrave;re d&#39;&eacute;valuation secondaire).<\/td>\n<td>-4&#x002C;3 contre -3&#x002C;5 jours<br \/> Diff&eacute;rence de -0&#x002C;8 jours (IC &agrave; 95% de -1&#x002C;46 &agrave; -0&#x002C;20)<\/p>\n<p> 49% contre 41%<br \/> Diff&eacute;rence de 8%<br \/> (IC &agrave; 95% de 0 &agrave; 15&#x002C; p=0&#x002C;044)<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<h3>Le rim&eacute;g&eacute;pant compar&eacute; &agrave; d&#39;autres traitements prophylactiques de la migraine<\/h3>\n<ul>\n<li>\n<p>L&#39;effet du rim&eacute;g&eacute;pant semble &ecirc;tre du m&ecirc;me ordre de grandeur que celui d&rsquo;<strong>autres traitements prophylactiques de la migraine<\/strong>&#x002C; mais les populations ne sont pas toujours comparables (notamment en ce qui concerne le nombre de crises de migraine par mois). Des &eacute;tudes randomis&eacute;es comparatives directes sont n&eacute;cessaires pour d&eacute;finir la place du rim&eacute;g&eacute;pant au sein de l&#39;arsenal th&eacute;rapeutique pour la prophylaxie antimigraineuse. Sa forme d&#39;administration orale pourrait repr&eacute;senter un avantage par rapport aux anticorps monoclonaux&#x002C; mais ceci n&rsquo;a pas fait l&rsquo;objet d&rsquo;&eacute;tudes randomis&eacute;es comparatives. Une &eacute;tude comparative avec le galcan&eacute;zumab est en cours (<a href='https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05127486'>CHALLENGE-MIG<\/a>)<sup><span class='folia-referentie-nummer'>6<\/span><\/sup>.<\/p>\n<\/li>\n<\/ul>\n<h3>Les effets &agrave; long terme du rim&eacute;g&eacute;pant en prophylaxie antimigraineuse<\/h3>\n<ul>\n<li>\n<p>L&rsquo;&eacute;tude en question ne durait que trois mois&#x002C; ce qui est tr&egrave;s court pour se prononcer sur l&#39;utilit&eacute; du rim&eacute;g&eacute;pant en prophylaxie antimigraineuse. Nous n&#39;avons trouv&eacute; aucune &eacute;tude publi&eacute;e ayant &eacute;valu&eacute; le rim&eacute;g&eacute;pant sur une p&eacute;riode de suivi plus longue.<br \/> &nbsp;<\/p>\n<\/li>\n<\/ul>\n<h2>Profil d&rsquo;innocuit&eacute; du rim&eacute;g&eacute;pant<\/h2>\n<div class='summary'>Le rim&eacute;g&eacute;pant semble bien tol&eacute;r&eacute; dans les &eacute;tudes randomis&eacute;es. Des r&eacute;actions d&#39;hypersensibilit&eacute; s&eacute;v&egrave;res peuvent survenir lorsqu&rsquo;il est utilis&eacute; en aigu. Il faut attendre les r&eacute;sultats d&rsquo;&eacute;tudes post-commercialisation pour pouvoir &eacute;valuer la s&eacute;curit&eacute; d&#39;utilisation &agrave; long terme (plus de 3 mois)&#x002C; en particulier chez les patients &agrave; risque cardiovasculaire&#x002C; en raison du risque th&eacute;orique d&#39;un effet vasoconstricteur associ&eacute; aux inhibiteurs du CGRP. La co-administration du rim&eacute;g&eacute;pant avec d&#39;autres inhibiteurs du CGRP ou avec un triptan doit &eacute;galement &ecirc;tre mieux document&eacute;e en termes de s&eacute;curit&eacute;.<\/div>\n<ul>\n<li>\n<p>Dans les &eacute;tudes randomis&eacute;es ayant &eacute;valu&eacute; le rim&eacute;g&eacute;pant en <b>traitement de crise&#x002C; <\/b>le rim&eacute;g&eacute;pant &eacute;tait bien tol&eacute;r&eacute; : 10&#x002C;8% des patients ont pr&eacute;sent&eacute; des effets ind&eacute;sirables suite &agrave; une prise unique de rim&eacute;g&eacute;pant&#x002C; contre 8&#x002C;6% avec le placebo<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: NL-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: FR-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019> ADDIN EN.CITE <EndNote><Cite><Author>EMA<\/Author><RecNum>26646<\/RecNum><DisplayText>\n\n<style face='superscript'>3<\/style>\n\n<\/DisplayText><record><rec-number>26646<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>26646<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>EMA&#x002C;<\/author><\/authors><\/contributors><titles><title>EPAR-Assessment Report Vydura\u00ae<\/title><\/titles><dates><\/dates><urls><related-urls><url>https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/vydura<\/url><\/related-urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=26646.pdf<\/url><\/pdf-urls><\/urls><\/record><\/Cite><\/EndNote><\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: NL-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>3<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: NL-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-end\u2019><\/span><\/span><![endif]-->. Les effets ind&eacute;sirables les plus fr&eacute;quemment rapport&eacute;s &eacute;taient&nbsp;: naus&eacute;es (1&#x002C;2% contre 0&#x002C;8% avec le placebo) et infections des voies urinaires (0&#x002C;8% contre 0&#x002C;3% avec le placebo).<\/p>\n<\/li>\n<li>\n<p>La s&eacute;curit&eacute; du <b>traitement prophylactique <\/b>est encore peu document&eacute;e pour l&rsquo;instant. La seule &eacute;tude randomis&eacute;e disponible<!--[if supportFields]><span style=\u2019font-size:12.0pt; line-height:150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin;color:#222222;mso-ansi-language:NL-BE;mso-fareast-language:NL-BE; mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: FR-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019> ADDIN EN.CITE <EndNote><Cite><Author>Croop<\/Author><Year>2021<\/Year><RecNum>22563<\/RecNum><DisplayText>\n\n<style face='superscript'>16<\/style>\n\n<\/DisplayText><record><rec-number>22563<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>22563<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>Croop&#x002C;R. <\/author><author>Lipton&#x002C;R. B. <\/author><author>Kudrow&#x002C;D. <\/author><author>Stock&#x002C;D. A. <\/author><author>Kamen&#x002C;L. <\/author><author>Conway&#x002C;C. M. <\/author><author>Stock&#x002C;E. G. <\/author><author>Coric&#x002C;V. <\/author><author>Goadsby&#x002C;P. J. <\/author><\/authors><\/contributors><auth-address>Biohaven Pharmaceuticals&#x002C; New Haven&#x002C; CT&#x002C; USA. Electronic address: robert.croop@biohavenpharma.com. Department of Neurology&#x002C; Albert Einstein College of Medicine&#x002C; Bronx&#x002C; NY&#x002C; USA. California Medical Clinic for Headache&#x002C; Santa Monica&#x002C; CA&#x002C; USA. Biohaven Pharmaceuticals&#x002C; New Haven&#x002C; CT&#x002C; USA. NIHR-Wellcome Trust King&apos;s Clinical Research Facility&#x002C; King&apos;s College Hospital\/SLaM Biomedical Research Centre&#x002C; King&apos;s College London&#x002C; UK; University of California&#x002C; Los Angeles&#x002C; Los Angeles&#x002C; CA&#x002C; USA.<\/auth-address><titles><title>Oral rimegepant for preventive treatment of migraine: a phase 2\/3&#x002C; randomised&#x002C; double-blind&#x002C; placebo-controlled trial<\/title><secondary-title>Lancet<\/secondary-title><\/titles><pages>51-60<\/pages><volume>397<\/volume><number>10268<\/number><dates><year>2021<\/year><\/dates><urls><related-urls><url>https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33338437<\/url><\/related-urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=22563.pdf<\/url><\/pdf-urls><\/urls><electronic-resource-num>10.1016\/S0140-6736(20)32544-7<\/electronic-resource-num><access-date>2021\/01\/02 tot 2021\/01\/15<\/access-date><modified-date>H\u00b0 Zen; TF Mig<\/modified-date><\/record><\/Cite><\/EndNote><\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: NL-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>16<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: NL-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-end\u2019><\/span><\/span><![endif]--> ne durait que 3&nbsp;mois et n&#39;a montr&eacute; aucune diff&eacute;rence entre le rim&eacute;g&eacute;pant et le placebo en ce qui concerne la survenue d&rsquo;effets ind&eacute;sirables (36% des patients dans les deux groupes).<\/p>\n<\/li>\n<li>\n<p>Les donn&eacute;es issues des &eacute;tudes randomis&eacute;es sont insuffisantes pour se prononcer sur le risque d&#39;<b>effets ind&eacute;sirables graves <\/b>avec le rim&eacute;g&eacute;pant en traitement de crise<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height: 150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin;color:#222222;mso-ansi-language:NL-BE;mso-fareast-language:NL-BE; mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: FR-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019> ADDIN EN.CITE <EndNote><Cite><Author>Halker Singh<\/Author><Year>2020<\/Year><RecNum>27247<\/RecNum><DisplayText>\n\n<style face='superscript'>17<\/style>\n\n<\/DisplayText><record><rec-number>27247<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>27247<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>Halker Singh&#x002C;Rashmi<\/author><author>VanderPluym&#x002C;Juliana H. <\/author><author>Morrow&#x002C;Allison S. <\/author><author>Urtecho&#x002C;Meritxell<\/author><author>Nayfeh&#x002C;Tarek<\/author><author>et al&#x002C;<\/author><\/authors><\/contributors><titles><title>Acute treatments for episodic migraine. Comparative Effectiveness Review. Number 239<\/title><secondary-title>AHRQ<\/secondary-title><\/titles><volume>December<\/volume><dates><year>2020<\/year><\/dates><urls><related-urls><url>https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK566246\/<\/url><\/related-urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=27247.pdf<\/url><\/pdf-urls><\/urls><\/record><\/Cite><\/EndNote><\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: NL-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>17<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: NL-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-end\u2019><\/span><\/span><![endif]-->. Dans l&#39;&eacute;tude ayant &eacute;valu&eacute; le traitement prophylactique<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: NL-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: FR-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019> ADDIN EN.CITE <EndNote><Cite><Author>Croop<\/Author><Year>2021<\/Year><RecNum>22563<\/RecNum><DisplayText>\n\n<style face='superscript'>16<\/style>\n\n<\/DisplayText><record><rec-number>22563<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>22563<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>Croop&#x002C;R. <\/author><author>Lipton&#x002C;R. B. <\/author><author>Kudrow&#x002C;D. <\/author><author>Stock&#x002C;D. A. <\/author><author>Kamen&#x002C;L. <\/author><author>Conway&#x002C;C. M. <\/author><author>Stock&#x002C;E. G. <\/author><author>Coric&#x002C;V. <\/author><author>Goadsby&#x002C;P. J. <\/author><\/authors><\/contributors><auth-address>Biohaven Pharmaceuticals&#x002C; New Haven&#x002C; CT&#x002C; USA. Electronic address: robert.croop@biohavenpharma.com. Department of Neurology&#x002C; Albert Einstein College of Medicine&#x002C; Bronx&#x002C; NY&#x002C; USA. California Medical Clinic for Headache&#x002C; Santa Monica&#x002C; CA&#x002C; USA. Biohaven Pharmaceuticals&#x002C; New Haven&#x002C; CT&#x002C; USA. NIHR-Wellcome Trust King&apos;s Clinical Research Facility&#x002C; King&apos;s College Hospital\/SLaM Biomedical Research Centre&#x002C; King&apos;s College London&#x002C; UK; University of California&#x002C; Los Angeles&#x002C; Los Angeles&#x002C; CA&#x002C; USA.<\/auth-address><titles><title>Oral rimegepant for preventive treatment of migraine: a phase 2\/3&#x002C; randomised&#x002C; double-blind&#x002C; placebo-controlled trial<\/title><secondary-title>Lancet<\/secondary-title><\/titles><pages>51-60<\/pages><volume>397<\/volume><number>10268<\/number><dates><year>2021<\/year><\/dates><urls><related-urls><url>https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33338437<\/url><\/related-urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=22563.pdf<\/url><\/pdf-urls><\/urls><electronic-resource-num>10.1016\/S0140-6736(20)32544-7<\/electronic-resource-num><access-date>2021\/01\/02 tot 2021\/01\/15<\/access-date><modified-date>H\u00b0 Zen; TF Mig<\/modified-date><\/record><\/Cite><\/EndNote><\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: NL-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>16<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: NL-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-end\u2019><\/span><\/span><![endif]-->&#x002C; la fr&eacute;quence d&rsquo;apparition des effets ind&eacute;sirables graves &eacute;tait similaire pour le rim&eacute;g&eacute;pant et le placebo (1%). Des &eacute;tudes &agrave; plus grande &eacute;chelle sont n&eacute;cessaires pour le confirmer.<\/p>\n<\/li>\n<li>\n<p>L&rsquo;effet apr&egrave;s l&#39;<b>arr&ecirc;t du traitement<\/b> ou le ph&eacute;non&egrave;me de rebond (augmentation du nombre de crises de migraine) en cas d&rsquo;arr&ecirc;t brutal n&rsquo;ont pas &eacute;t&eacute; &eacute;tudi&eacute;s. Aucun indice de rebond n&rsquo;a &eacute;t&eacute; identifi&eacute; dans les &eacute;tudes disponibles. Aucun signal sugg&eacute;rant <b>une<\/b> <b>surconsommation ou un m&eacute;susage<\/b> de rim&eacute;gepant n&#39;a &eacute;t&eacute; rapport&eacute; lors d&#39;une administration &agrave; long terme<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: NL-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: FR-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019> ADDIN EN.CITE <EndNote><Cite><Author>EMA<\/Author><RecNum>26646<\/RecNum><DisplayText>\n\n<style face='superscript'>3<\/style>\n\n<\/DisplayText><record><rec-number>26646<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>26646<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>EMA&#x002C;<\/author><\/authors><\/contributors><titles><title>EPAR-Assessment Report Vydura\u00ae<\/title><\/titles><dates><\/dates><urls><related-urls><url>https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/vydura<\/url><\/related-urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=26646.pdf<\/url><\/pdf-urls><\/urls><\/record><\/Cite><\/EndNote><\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: NL-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>3<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin;color:#222222;mso-ansi-language: NL-BE;mso-fareast-language:NL-BE;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-end\u2019><\/span><\/span><![endif]-->. Ces questions doivent faire l&#39;objet d&#39;un suivi plus approfondi dans le cadre d&#39;&eacute;tudes post-commercialisation.<\/p>\n<\/li>\n<li>\n<p>Des <b>r&eacute;actions d&#39;hypersensibilit&eacute;<\/b>&#x002C; incluant dyspn&eacute;e et &eacute;ruption cutan&eacute;e s&eacute;v&egrave;re&#x002C; peuvent survenir plusieurs jours apr&egrave;s l&#39;administration. Elles sont survenues chez moins de 1% des patients dans les &eacute;tudes cliniques<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span> ADDIN EN.CITE <EndNote><Cite><RecNum>26645<\/RecNum><DisplayText>\n\n<style face='superscript'>18<\/style>\n\n<\/DisplayText><record><rec-number>26645<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>26645<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><\/contributors><titles><title>Vydura\u00ae - Samenvatting van de Kenmerken van het Product<\/title><\/titles><dates><\/dates><urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=26645.pdf<\/url><\/pdf-urls><\/urls><\/record><\/Cite><\/EndNote><span style=\u2019mso-element:field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>18<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]-->.<\/p>\n<\/li>\n<li>\n<p>Contrairement aux triptans&#x002C; le rim&eacute;g&eacute;pant n&#39;est pas contre-indiqu&eacute; en cas de <b>maladie cardiovasculaire<\/b><!--[if supportFields]><span style=\u2019font-size:12.0pt; line-height:150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family: 'Times New Roman';mso-ansi-language:NL-BE;mso-fareast-language:EN-US; mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element:field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:FR-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019> ADDIN EN.CITE <EndNote><Cite><Author>Schwarz<\/Author><Year>2022<\/Year><RecNum>26417<\/RecNum><DisplayText>\n\n<style face='superscript'>2<\/style>\n\n<\/DisplayText><record><rec-number>26417<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>26417<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>Schwarz&#x002C;E. P. <\/author><\/authors><\/contributors><titles><title>Nieuw geneesmiddel: rimegepant bij migraineaanvallen<\/title><secondary-title>Geneesmiddelenbulletin<\/secondary-title><\/titles><pages>65-8<\/pages><volume>8<\/volume><dates><year>2022<\/year><\/dates><urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=26417.pdf<\/url><\/pdf-urls><\/urls><access-date>2022\/08\/02 tot 2022\/08\/15<\/access-date><modified-date>H\u00b0 Psy; ISDB<\/modified-date><\/record><\/Cite><\/EndNote><\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>2<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]-->. &Eacute;tant donn&eacute; que les &eacute;tudes ont exclu les patients pr&eacute;sentant une maladie cardiovasculaire non contr&ocirc;l&eacute;e&#x002C; instable&#x002C; r&eacute;cemment diagnostiqu&eacute;e ou s&eacute;v&egrave;re&#x002C; la s&eacute;curit&eacute; d&rsquo;utilisation dans cette population reste toutefois incertaine<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height: 150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family: 'Times New Roman';mso-ansi-language:FR-BE;mso-fareast-language:EN-US; mso-bidi-language:AR-SA\u2019> ADDIN EN.CITE <EndNote><Cite><Author>EMA<\/Author><RecNum>26646<\/RecNum><DisplayText>\n\n<style face='superscript'>3<\/style>\n\n<\/DisplayText><record><rec-number>26646<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>26646<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>EMA&#x002C;<\/author><\/authors><\/contributors><titles><title>EPAR-Assessment Report Vydura\u00ae<\/title><\/titles><dates><\/dates><urls><related-urls><url>https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/vydura<\/url><\/related-urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=26646.pdf<\/url><\/pdf-urls><\/urls><\/record><\/Cite><\/EndNote><\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>3<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]-->.<\/p>\n<\/li>\n<li>\n<p>Il n&#39;est pas possible de se prononcer sur la s&eacute;curit&eacute; de l&#39;utilisation combin&eacute;e de rim&eacute;g&eacute;pant et de <b>triptans<\/b> en raison du manque de donn&eacute;es. Dans les &eacute;tudes sur le rim&eacute;g&eacute;pant en traitement de crise&#x002C; les triptans n&#39;&eacute;taient pas autoris&eacute;s dans les 48 heures suivant la prise de rim&eacute;g&eacute;pant. Dans l&#39;&eacute;tude sur le rim&eacute;g&eacute;pant en prophylaxie antimigraineuse&#x002C; les triptans &eacute;taient autoris&eacute;s&#x002C; mais les auteurs ne mentionnent pas &agrave; quelle fr&eacute;quence ils ont &eacute;t&eacute; pris (dans le groupe rim&eacute;g&eacute;pant&#x002C; des &laquo;&nbsp;m&eacute;dicaments de secours&nbsp;&raquo;&nbsp;(rescue) ont &eacute;t&eacute; utilis&eacute;s pendant 3&#x002C;7 jours au cours du dernier mois de l&#39;&eacute;tude&#x002C; contre 4 jours dans le groupe placebo&#x002C; une diff&eacute;rence qui n&rsquo;&eacute;tait pas statistiquement significative).<\/p>\n<\/li>\n<li>\n<p>Concernant l&#39;utilisation concomitante du rim&eacute;g&eacute;pant avec des <b>anticorps monoclonaux <\/b>en prophylaxie antimigraineuse&#x002C; les donn&eacute;es disponibles sont rassurantes mais elles sont trop limit&eacute;es et de trop courte dur&eacute;e pour pouvoir se prononcer sur la s&eacute;curit&eacute; d&rsquo;une telle utilisation<!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-begin\u2019><\/span><\/span><span lang=FR-BE style=\u2019font-size:12.0pt;line-height: 150%;font-family:'Calibri'&#x002C;sans-serif;mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family: 'Times New Roman';mso-ansi-language:FR-BE;mso-fareast-language:EN-US; mso-bidi-language:AR-SA\u2019> ADDIN EN.CITE <EndNote><Cite><Author>Cohen<\/Author><Year>2022<\/Year><RecNum>27249<\/RecNum><DisplayText>\n\n<style face='superscript'>6<\/style>\n\n<\/DisplayText><record><rec-number>27249<\/rec-number><foreign-keys><key app='EN' db-id='9estwffrmd2vsler0f4pa2de25fzxpr005sw' timestamp='0'>27249<\/key><\/foreign-keys><ref-type name='Journal Article'>17<\/ref-type><contributors><authors><author>Cohen&#x002C;Fred<\/author><author>Yuan&#x002C;Hsiangkuo<\/author><author>Silberstein&#x002C;Stephen D<\/author><\/authors><\/contributors><auth-address>Jefferson Headache Center&#x002C; Department of Neurology&#x002C; Thomas Jefferson University&#x002C; 900 Walnut Street&#x002C; Suite 200&#x002C; Philadelphia&#x002C; PA&#x002C; 19107&#x002C; USA.<\/auth-address><titles><title>Calcitonin Gene-Related Peptide (CGRP)-targeted monoclonal antibodies and antagonists in migraine: current evidence and rationale.<\/title><secondary-title>BioDrugs<\/secondary-title><\/titles><pages>341-358<\/pages><volume>36<\/volume><number>3<\/number><dates><year>2022<\/year><\/dates><urls><related-urls><url>https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35476215<\/url><\/related-urls><pdf-urls><url>https:\/\/lib.bcfi-cbip.be\/librarian\/pdfviewer.php?file=27249.pdf<\/url><\/pdf-urls><\/urls><electronic-resource-num>10.1007\/s40259-022-00530-0<\/electronic-resource-num><\/record><\/Cite><\/EndNote><\/span><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-separator\u2019><\/span><\/span><![endif]--><span class='folia-referentie-nummer'><sup>6<\/sup><\/span><!--[if supportFields]><span style=\u2019font-size:12.0pt;line-height:150%;font-family:'Calibri'&#x002C;sans-serif; mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-hansi-theme-font: minor-latin;mso-bidi-font-family:'Times New Roman';mso-ansi-language:NL-BE; mso-fareast-language:EN-US;mso-bidi-language:AR-SA\u2019><span style=\u2019mso-element: field-end\u2019><\/span><\/span><![endif]-->. La prudence s&#39;impose car le CGRP est impliqu&eacute; dans plusieurs processus physiologiques et l&#39;association d&rsquo;inhibiteurs du CGRP pourrait th&eacute;oriquement entra&icirc;ner une hypertension ou des accidents isch&eacute;miques. Des &eacute;tudes &agrave; long terme sur des populations plus importantes sont n&eacute;cessaires pour d&eacute;terminer dans quels sous-groupes la th&eacute;rapie combin&eacute;e peut repr&eacute;senter un b&eacute;n&eacute;fice et dans quels sous-groupes elle peut au contraire exposer &agrave; des risques suppl&eacute;mentaires.<span class='folia-referentie-note'>19<\/span><\/p>\n<\/li>\n<li>\n<p>L&rsquo;utilisation du rim&eacute;g&eacute;pant pendant la <b>grossesse <\/b>n&rsquo;est pas suffisamment document&eacute;e. Par mesure de pr&eacute;caution&#x002C; le rim&eacute;g&eacute;pant est d&eacute;conseill&eacute;.<\/p>\n<\/li>\n<li>\n<p><b>Interactions&nbsp;<\/b>: le rim&eacute;g&eacute;pant est un substrat du CYP3A4 et de la P-gp. La co-administration avec des inhibiteurs puissants du CYP3A4 ou avec des inducteurs puissants ou mod&eacute;r&eacute;s du CYP3A4 n&#39;est pas recommand&eacute;e. En cas d&#39;utilisation concomitante d&#39;inhibiteurs mod&eacute;r&eacute;s du CYP3A4 ou d&#39;inhibiteurs puissants de la P-gp&#x002C; il faut &eacute;viter la prise d&#39;une 2<sup>e<\/sup> dose de rim&eacute;g&eacute;pant dans les 48&nbsp;heures (voir Tableau Ic et Tableau Id dans <a href='https:\/\/www.cbip.be\/fr\/chapters\/1?frag=9990243'>l&#39;Introduction 6.3<\/a>).<\/p>\n<\/li>\n<li>\n<p><b>Pr&eacute;cautions particuli&egrave;res <\/b>: le rim&eacute;g&eacute;pant doit &ecirc;tre &eacute;vit&eacute; chez les patients pr&eacute;sentant une insuffisance h&eacute;patique s&eacute;v&egrave;re<br \/> &nbsp;<\/p>\n<\/li>\n<\/ul>\n<h2>Commentaires du CBIP<\/h2>\n<ul>\n<li>\n<p>Nos messages concernant le rim&eacute;g&eacute;pant rejoignent en grande partie ceux que nous avions donn&eacute;s au sujet des anticorps monoclonaux dans la migraine [voir <a href='https:\/\/www.cbip.be\/fr\/articles\/3662?folia=3658'>Folia d&rsquo;ao&ucirc;t 2021<\/a>]. Il est probable que ce nouveau m&eacute;dicament aura un int&eacute;r&ecirc;t chez certains patients&#x002C; mais les caract&eacute;ristiques qui distinguent les &laquo;&nbsp;r&eacute;pondeurs&nbsp;&raquo; des &laquo;&nbsp;non-r&eacute;pondeurs&nbsp;&raquo; restent &agrave; &eacute;lucider. Ceci doit &ecirc;tre approfondi dans le cadre de recherches futures.<\/p>\n<\/li>\n<li>\n<p>Parmi les patients souffrant d&#39;une crise de migraine&#x002C; 19&nbsp;&agrave; 31% des patients ne ressentent plus de douleur deux heures apr&egrave;s la prise de rim&eacute;g&eacute;pant&#x002C; soit 5 &agrave; 16% de plus qu&#39;avec le placebo. L&#39;effet semble &ecirc;tre du m&ecirc;me ordre de grandeur que celui d&#39;autres antimigraineux&#x002C; mais pour pouvoir en juger&#x002C; il faudrait des &eacute;tudes portant sur des populations comparables. Des &eacute;tudes comparatives directes sont n&eacute;cessaires pour mieux cerner la place du rim&eacute;g&eacute;pant au sein de l&#39;arsenal th&eacute;rapeutique.<\/p>\n<\/li>\n<li>\n<p>Le traitement par rim&eacute;g&eacute;pant pourrait s&rsquo;av&eacute;rer b&eacute;n&eacute;fique chez les patients migraineux qui ne r&eacute;pondent pas &agrave; d&rsquo;autres traitements ou qui pr&eacute;sentent des contre-indications &agrave; ces traitements&#x002C; mais ce groupe de patients n&rsquo;a pas fait l&rsquo;objet d&rsquo;&eacute;tudes randomis&eacute;es. Des recherches suppl&eacute;mentaires sont &eacute;galement n&eacute;cessaires en ce qui concerne les risques et les b&eacute;n&eacute;fices li&eacute;s &agrave; l&rsquo;utilisation concomitante d&rsquo;anticorps monoclonaux.<\/p>\n<\/li>\n<li>\n<p>Le rim&eacute;g&eacute;pant utilis&eacute; en prophylaxie permet de diminuer le nombre de jours de migraine de moins d&#39;un jour par mois. M&ecirc;me si pour le patient&#x002C; chaque jour sans migraine est un jour de gagn&eacute;&#x002C; il est important de ne pas cr&eacute;er de faux espoirs. Il n&#39;y a aucune garantie de succ&egrave;s th&eacute;rapeutique et il ne s&rsquo;agit pas d&rsquo;un traitement curatif.<\/p>\n<\/li>\n<li>\n<p>La r&eacute;ponse au placebo dans une population de patients souffrant de migraine s&eacute;v&egrave;re est importante (les patients avaient en moyenne 4 &agrave; 4&#x002C;6 crises de migraine par mois &agrave; l&rsquo;inclusion dans les &eacute;tudes sur la migraine aigu&euml; et en moyenne 10 jours de migraine par mois dans l&#39;&eacute;tude sur la prophylaxie).<\/p>\n<\/li>\n<li>\n<p>On peut se demander si le b&eacute;n&eacute;fice du rim&eacute;g&eacute;pant est proportionnel &agrave; son prix &eacute;lev&eacute;&#x002C; qui&#x002C; &agrave; environ 30 &euro; par comprim&eacute;&#x002C; est beaucoup plus &eacute;lev&eacute; que celui de la plupart des autres m&eacute;dicaments antimigraineux (sauf des anticorps monoclonaux). Le co&ucirc;t social de la migraine s&eacute;v&egrave;re doit &ecirc;tre pris en compte dans cette &eacute;valuation.<\/p>\n<\/li>\n<li>\n<p>La migraine &eacute;tant une affection chronique&#x002C; il est fort probable que le traitement prophylactique sera pris pendant des ann&eacute;es. Les &eacute;tudes contr&ocirc;l&eacute;es par placebo n&rsquo;ont &eacute;valu&eacute; le rim&eacute;g&eacute;pant que sur une dur&eacute;e de tout au plus 3 mois&#x002C; ce qui laisse de nombreux points d&#39;interrogation quant &agrave; son efficacit&eacute; et sa s&eacute;curit&eacute; d&#39;emploi &agrave; long terme. En outre&#x002C; il n&#39;existe pas d&#39;&eacute;tudes de bonne qualit&eacute; m&eacute;thodologique sur l&rsquo;effet apr&egrave;s l&#39;arr&ecirc;t du traitement.<\/p>\n<\/li>\n<li>\n<p>Les &eacute;tudes cliniques n&#39;ont pas r&eacute;v&eacute;l&eacute; d&#39;effets ind&eacute;sirables graves&#x002C; mais elles portaient sur une population s&eacute;lectionn&eacute;e. Il faut attendre les r&eacute;sultats d&rsquo;&eacute;tudes post-commercialisation pour pouvoir se prononcer sur la s&eacute;curit&eacute; du rim&eacute;g&eacute;pant&#x002C; en particulier chez les patients atteints de maladies cardiovasculaires graves ou de troubles psychiatriques.<\/p>\n<\/li>\n<li>\n<p>Il n&#39;est pas possible de se prononcer sur le profil d&rsquo;efficacit&eacute; et d&rsquo;innocuit&eacute; des antagonistes des r&eacute;cepteurs du CGRP chez les enfants et les adolescents en raison de l&#39;absence d&#39;&eacute;tudes randomis&eacute;es.<br \/> &nbsp;<\/p>\n<\/li>\n<\/ul>\n<h2>Sources<\/h2>\n<p><span class='folia-referentie-tekst'><span class='folia-referentie-nummer'>1&nbsp;<\/span>Heersche A&#x002C; Bijlstra-Cramer MA. Erenumab; de eerste CGRP-antagonist bij migraine. Pharma Selecta 2018;34:65-8.<\/span><br \/> <span class='folia-referentie-tekst'><span class='folia-referentie-nummer'>2&nbsp;&nbsp;<\/span>Schwarz EP. Nieuw geneesmiddel: rimegepant bij migraineaanvallen. Geneesmiddelenbulletin 2022;8:65-8.<br \/> <span class='folia-referentie-nummer'>3&nbsp;<\/span>EMA. EPAR-Assessment Report Vydura&reg;. <a href='https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/vydura'>https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/vydura<\/a><br \/> <span class='folia-referentie-nummer'>4<\/span>&nbsp;The Medical Letter on Drugs and Therapeutics. Rimegepant (Nurtec ODT) for acute treatment of migraine. The Medical Letter on Drugs and Therapeutics 2020;62:70-2. <a href='https:\/\/secure.medicalletter.org\/TML-article-1597d'>https:\/\/secure.medicalletter.org\/TML-article-1597d<\/a><br \/> <span class='folia-referentie-nummer'>5<\/span>&nbsp;Mullin K&#x002C; Kudrow D&#x002C; Croop R&#x002C; et al. Potential for treatment benefit of small molecule CGRP receptor antagonist plus monoclonal antibody in migraine therapy. Neurology 2020;94:e2121-e5.doi:10.1212\/WNL.0000000000008944<\/span><br \/> <span class='folia-referentie-tekst'><span class='folia-referentie-nummer'>6<\/span>&nbsp;Cohen F&#x002C; Yuan H&#x002C; Silberstein SD. Calcitonin Gene-Related Peptide (CGRP)-targeted monoclonal antibodies and antagonists in migraine: current evidence and rationale. BioDrugs 2022;36:341-58.doi:10.1007\/s40259-022-00530-0<br \/> <span class='folia-referentie-nummer'>7<\/span>&nbsp;Marcus R&#x002C; Goadsby PJ&#x002C; Dodick D&#x002C; et al. BMS-927711 for the acute treatment of migraine: a double-blind&#x002C; randomized&#x002C; placebo controlled&#x002C; dose-ranging trial. Cephalalgia 2014;34:114-25.doi:10.1177\/0333102413500727<br \/> <span class='folia-referentie-nummer'>8<\/span>&nbsp;Yang C-P&#x002C; Liang C-S&#x002C; Chang C-M&#x002C; et al. Comparison of new pharmacologic agents with triptans for treatment of migraine: a systematic review and meta-analysis. JAMA Netw Open 2021;4:e2128544.doi:10.1001\/jamanetworkopen.2021.28544<br \/> <span class='folia-referentie-nummer'>9<\/span>&nbsp;Lipton RB&#x002C; Croop R&#x002C; Stock EG&#x002C; et al. Rimegepant&#x002C; an oral calcitonin gene-related peptide receptor antagonist&#x002C; for migraine. N Engl J Med 2019;381:142-9.doi:10.1056\/NEJMoa1811090<br \/> <span class='folia-referentie-nummer'>10<\/span>&nbsp;Croop R&#x002C; Goadsby PJ&#x002C; Conway CM&#x002C; et al. Efficacy&#x002C; safety&#x002C; and tolerability of rimegepant orally disintegrating tablet for the acute treatment of migraine: a randomised&#x002C; phase 3&#x002C; double-blind&#x002C; placebo-controlled trial. The Lancet 2019;31:737-45.doi:<a href='https:\/\/doi.org\/10.1016\/S0140-6736(19)31606-X'>https:\/\/doi.org\/10.1016\/S0140-6736(19)31606-X<\/a><br \/> <span class='folia-referentie-nummer'>11<\/span>VanderPluym JH&#x002C; Halker Singh RB&#x002C; Urtecho M&#x002C; et al. Acute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis. JAMA 2021;325:2357-69.doi:10.1001\/jama.2021.7939<br \/> <span class='folia-referentie-nummer'>12<\/span>&nbsp;Gao B&#x002C; Yang Y&#x002C; Wang Z&#x002C; et al. Efficacy and safety of rimegepant for the acute treatment of migraine: evidence from randomized controlled trials. Front Pharmacol 2020;10:1577.doi:10.3389\/fphar.2019.01577<br \/> <span class='folia-referentie-nummer'>13<\/span>&nbsp;Derry CJ&#x002C; Derry S&#x002C; Moore RA. Sumatriptan (oral route of administration) for acute migraine attacks in adults. Cochrane Database Syst Rev 2012;2:CD008615.doi:10.1002\/14651858.CD008615.pub2<br \/> <span class='folia-referentie-nummer'>14<\/span>&nbsp;McCarthy L. Orally disintegrating rimegepant increased freedom from pain and from most bothersome symptom at 2 h in acute migraine. Annals of Internal Medicine 2019;171:JC58-JC.doi:10.7326\/ACPJ201911190-058<br \/> <span class='folia-referentie-nummer'>15<\/span>&nbsp;Johnston K&#x002C; Harris L&#x002C; Powell L&#x002C; et al. Monthly migraine days&#x002C; tablet utilization&#x002C; and quality of life associated with Rimegepant &#8211; post hoc results from an open label safety study (BHV3000-201). J Headache Pain 2022;23:10.doi:10.1186\/s10194-021-01378-5<br \/> <span class='folia-referentie-nummer'>16<\/span>&nbsp;Croop R&#x002C; Lipton RB&#x002C; Kudrow D&#x002C; et al. Oral rimegepant for preventive treatment of migraine: a phase 2\/3&#x002C; randomised&#x002C; double-blind&#x002C; placebo-controlled trial. Lancet 2021;397:51-60.doi:10.1016\/S0140-6736(20)32544-7<br \/> <span class='folia-referentie-nummer'>17<\/span>&nbsp;Halker Singh R&#x002C; VanderPluym JH&#x002C; Morrow AS&#x002C; et al. Acute treatments for episodic migraine. Comparative Effectiveness Review. Number 239. AHRQ 2020;December. <a href='https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK566246\/'>https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK566246\/<\/a><br \/> <span class='folia-referentie-nummer'>18<\/span>&nbsp;Anonymous. Vydura&reg; &#8211; Samenvatting van de Kenmerken van het Product.<br \/> <span class='folia-referentie-nummer'>19<\/span>&nbsp;Pellesi L. Combining two CGRP inhibitors to treat migraine. Expert Opinion on Drug Safety 2022;21:1135-36.doi:10.1080\/14740338.2022.2130890<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Le rim&eacute;g&eacute;pant appartient &agrave; la classe des antagonistes des r&eacute;cepteurs  [&#8230;]<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,14914],"tags":[20213,20224],"class_list":["post-175321","post","type-post","status-publish","format-standard","hentry","category-actualites","category-2023-fr","tag-import_tags","tag-import_tags-nl"],"_links":{"self":[{"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/posts\/175321","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/comments?post=175321"}],"version-history":[{"count":2,"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/posts\/175321\/revisions"}],"predecessor-version":[{"id":180279,"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/posts\/175321\/revisions\/180279"}],"wp:attachment":[{"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/media?parent=175321"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/categories?post=175321"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/h.cbip.be\/fr\/wp-json\/wp\/v2\/tags?post=175321"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}